The human digestive system consists of a complex series of organs and glands regulating the processing of food. The process starts in the mouth, where the food breaks down by chewing, and the digestive enzymes in the saliva. Then in the stomach the gastric phase of digestion takes place. At the final stage the food is mixed with enzymes produced by the pancreas, after which the content passes the gastrointestinal tract. The undigested food particles end up in the large intestine, where they are fermented by the gut microbiome, consisting of approximately thousand bacterial species. CarbExplore is an expert in manufacturing the potential prebiotic food components, Fructo-oligosaccharides (FOS), Galacto-oligosaccharides (GOS), and Isomalto-/maltopolysaccharides (IMMP). These potential prebiotic food components support the growth of the microorganisms that provide a health benefit.

CarbExplore has a library with a diverse range of Carbohydrate-Active Enzymes, like glucansucrases, glucanotransferases and fructosyltransferases. These enzymes are able to convert substrate molecules into the products of interest. We are able to tweak the carbohydrate structure and functions, making variable changes of the degree of polymerization (dp), branching rate, and glyosidic linkages (α1→2),  (α1→3), (α1→4) and (α1→6). Our scientists use several techniques (HPLC, HPAEC-PAD, NMR, MALDI-TOF, HP-SEC) to analyze and screen the product, processing the product of interest.

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Examples:

Change the degree of branching of amylopectin

Production and characterization of 4,6-α-GTases to produce IMMP

Use fructosyltransferases to synthesize fructan polymers from sucrose

Workflow:


You deliver:

Detailed project information about the product of interest.


We deliver:

A project plan with detailed descriptions.