CarbExplore and Nestlé collaboration delivers breakthrough enzyme technology

Developing novel α-Glucans for better health

The primary goal of the project was to develop new α-glucans with improved digestion properties, leading to an extended postprandial glycemic response and reduced blood glucose peaks. By slowing down carbohydrate digestion, these innovations support better blood sugar management—an essential factor in promoting metabolic health.

Scientific innovation and execution

CarbExplore applied its expertise in carbohydrate modification and carbohydrate-active enzymes to screen and identify promising enzyme candidates from Nestlé’s private culture collection. These enzymes were produced, characterized, and evaluated for their ability to generate α-glucans with slow digestibility properties. The research involved:

• Screening and characterizing novel enzymes

• Producing and testing modified starches for digestion rates

• Validating findings through human clinical trials

Key achievements

• Discovery of four novel α-glucanotransferases (2 GtfB and 2 GtfD enzymes)

• Development of modified starches that exhibited slow digestibility in in vitro studies, later confirmed in human trials

• Publication of seven peer-reviewed articles in high-impact scientific journals

• Securing three active patents to protect this innovative technology

A step toward healthier, sustainable food solutions

This successful collaboration reinforced Nestlé’s mission to develop plant-based, sustainable food solutions while positioning CarbExplore as a key innovator in biotechnology-driven ingredient development. By harnessing enzyme technology, we continue to provide clean-label alternatives that enhance both health and sustainability in the food industry.

Partner with us

At CarbExplore, we specialize in developing functional carbohydrates through cutting-edge enzyme technology. Interested in exploring new possibilities? Let’s innovate together!